Usually means: Current events or personal status.
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We found 9 dictionaries that define the word What's up:

General (8 matching dictionaries)
  1. what's up: Merriam-Webster
  2. what's up: Oxford Learner's Dictionaries
  3. what's up, what's up: Collins English Dictionary
  4. What's up: Cambridge Advanced Learner's Dictionary
  5. what's up: Wiktionary
  6. What's Up, What's Up, What's Up, What's Up (Myname song), What's Up (TV series), What's up, What's up, What's up (disambiguation): Wikipedia, the Free Encyclopedia
  7. What's up: Stammtisch Beau Fleuve Acronyms
  8. What's up: ESL Idiom Page

Slang (1 matching dictionary)
  1. What's Up, Whats up, Whats up, whats up: Urban Dictionary

Definitions from Wikipedia (What's Up)

noun:  an alternative weekly newspaper circulated every Wednesday in El Paso, Texas, Ciudad Juárez, México, and nearby Las Cruces, New Mexico.
noun:  a 2011 South Korean television series starring Lim Ju-hwan, Kang Dae-sung, Lim Ju-eun, Oh Man-seok, Jang Hee-jin, Kim Ji-won and Jo Jung-suk.
noun:  "What's Up" is a song by South Korean idol group Myname.
noun:  the final album by American jazz trumpeter Bill Hardman which was recorded in Copenhagen in 1989 and released on the Danish SteepleChase label.

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