Definitions from Wiktionary ( )

▸ adverb:  (interrogative) In what way; to what extent.
▸ adverb:  Used before a prepositional phrase to emphasise that something is taken into consideration as a cause or reason; usually used in combination with 'with' (see what with), and much less commonly with other prepositions.
▸ noun:  (obsolete, uncountable) Something; thing; stuff.
▸ noun:  (countable) The identity of a thing, as an answer to a question of what.
▸ noun:  (countable) Something that is addressed by what, as opposed to a person, addressed by who.

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