Usually means: Possessing profound knowledge and judgment.
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We found 15 dictionaries that define the word wisest:

General (10 matching dictionaries)
  1. wisest: Merriam-Webster.com
  2. wisest: Collins English Dictionary
  3. wisest: Vocabulary.com
  4. Wisest, wisest: Wordnik
  5. wisest: Cambridge Advanced Learner's Dictionary
  6. wisest: Wiktionary
  7. wisest: Dictionary.com
  8. wisest: Cambridge Essential American English Dictionary
  9. wisest: Free Dictionary
  10. wisest: Dictionary/thesaurus

Business (1 matching dictionary)
  1. wisest: Legal dictionary

Medicine (1 matching dictionary)
  1. wisest: Medical dictionary

Miscellaneous (2 matching dictionaries)
  1. WISEST: Acronym Finder
  2. wisest: Idioms

Slang (1 matching dictionary)
  1. wisest: Urban Dictionary

(Note: See wise as well.)

Definitions from Wiktionary (WISE)

adjective:  Showing good judgement or the benefit of experience.
adjective:  (colloquial, ironic, sarcastic) Disrespectful.
adjective:  (colloquial) Aware, informed (to something).
verb:  To become wise.
verb:  (ergative, slang) Usually with "up", to inform or learn.
noun:  (archaic) Way, manner, or method.
verb:  (dialectal) To instruct.
verb:  (dialectal) To advise; induce.
verb:  (dialectal) To show the way, guide.
verb:  (dialectal) To direct the course of, pilot.
verb:  (dialectal) To cause to turn.
noun:  A surname.
noun:  A township in Isabella County, Michigan, United States.
noun:  An unincorporated community in Warren County, North Carolina, United States.
noun:  A town, the county seat of Wise County, Virginia, United States.
noun:  (aviation, nautical) Acronym of wing-in-surface effect.
noun:  (space science, US) Acronym of Wide-field Infrared Survey Explorer. (a NASA infrared-wavelength astronomical space telescope that performed an all-sky astronomical survey with images in 3-22 μm wavelength bands)
▸ Also see wise

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