Usually means: Change or variation in circumstances.
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We found 25 dictionaries that define the word vicissitude:

General (22 matching dictionaries)
  1. vicissitude: Merriam-Webster.com
  2. vicissitude: Oxford Learner's Dictionaries
  3. vicissitude: American Heritage Dictionary of the English Language
  4. vicissitude: Collins English Dictionary
  5. vicissitude: Vocabulary.com
  6. Vicissitude, vicissitude: Wordnik
  7. vicissitude: Wiktionary
  8. vicissitude: Webster's New World College Dictionary, 4th Ed.
  9. vicissitude: The Wordsmyth English Dictionary-Thesaurus
  10. vicissitude: Infoplease Dictionary
  11. vicissitude: Dictionary.com
  12. vicissitude: Online Etymology Dictionary
  13. Vicissitude: Wikipedia, the Free Encyclopedia
  14. Vicissitude: Online Plain Text English Dictionary
  15. vicissitude: Webster's Revised Unabridged, 1913 Edition
  16. vicissitude: Rhymezone
  17. Vicissitude: AllWords.com Multi-Lingual Dictionary
  18. vicissitude: Webster's 1828 Dictionary
  19. vicissitude: Free Dictionary
  20. vicissitude: Mnemonic Dictionary
  21. vicissitude: LookWAYup Translating Dictionary/Thesaurus
  22. vicissitude: Dictionary/thesaurus

Business (1 matching dictionary)
  1. vicissitude: Legal dictionary

Miscellaneous (1 matching dictionary)
  1. vicissitude: A Word A Day

Slang (1 matching dictionary)
  1. vicissitude: Urban Dictionary

(Note: See vicissitudes as well.)

Definitions from Wiktionary (vicissitude)

noun:  Regular change or succession from one thing to another, or one part of a cycle to the next; alternation; mutual succession; interchange.
noun:  (often in the plural) A change, especially in one's life or fortunes.

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