Usually means: Direction opposite to gravitational pull.
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We found 58 dictionaries that define the word up:

General (29 matching dictionaries)
  1. up: Longman Dictionary of Contemporary English
  2. UP, up: Merriam-Webster
  3. up, up-: Oxford Learner's Dictionaries
  4. UP, up, up-: American Heritage Dictionary of the English Language
  5. up, up-: Collins English Dictionary
  6. up: Vocabulary.com
  7. UP, Up, up, up, up, up, uP: Wordnik
  8. up, up-: Cambridge Advanced Learner's Dictionary
  9. U.P, UP, up, up-: Wiktionary
  10. up, up-: Webster's New World College Dictionary, 4th Ed.
  11. up, up-: The Wordsmyth English Dictionary-Thesaurus
  12. up: Infoplease Dictionary
  13. UP, u.p, up, up-: Dictionary.com
  14. up-, up (adv.), up (v.): Online Etymology Dictionary
  15. up: Cambridge Essential American English Dictionary
  16. The Up, UP (TV channel), UP (complexity), UP, Up (ABC album), Up (Australian bank), Up (Great Big Sea album), Up (James Morrison song), Up (Olly Murs song), Up (Peter Gabriel album), Up (Pop Evil album), Up (R.E.M. album), Up (Right Said Fred album), Up (Soundtrack), Up (TV channel), Up (TV network), Up (TV program), Up (TV series), Up (The Saturdays song), Up (airline), Up (film), Up (film score), Up (film series), Up (video game), Up, Up, -up: Wikipedia, the Free Encyclopedia
  17. Up: Online Plain Text English Dictionary
  18. up: Webster's Revised Unabridged, 1913 Edition
  19. up: Rhymezone
  20. up: AllWords.com Multi-Lingual Dictionary
  21. up: Webster's 1828 Dictionary
  22. up, up-: MyWord.info
  23. U.P, UP, up, uP: Stammtisch Beau Fleuve Acronyms
  24. Up: Dictionary of Phrase and Fable (1898)
  25. up: FreeDictionary.org
  26. up: Mnemonic Dictionary
  27. UP, up-: TheFreeDictionary.com

Art (2 matching dictionaries)
  1. Glossary of Stamp Collecting Terms (No longer online)
  2. up: Seinfeld Dictionary

Business (3 matching dictionaries)
  1. MoneyGlossary.com (No longer online)
  2. UP (initialism), Up (album), Up, Up: Financial dictionary
  3. Glossary of Trade and Shipping Terms (No longer online)

Computing (6 matching dictionaries)
  1. up: Free On-line Dictionary of Computing
  2. up: Netlingo
  3. up: CCI Computer
  4. BABEL: Computer Oriented Abbreviations and Acronyms (No longer online)
  5. Webopedia (No longer online)
  6. UP (initialism), Up (album), Up, up: Encyclopedia

Medicine (2 matching dictionaries)
  1. UP: Merriam-Webster Medical Dictionary
  2. online medical dictionary (No longer online)

Miscellaneous (5 matching dictionaries)
  1. Brilliant Dream Dictionary (No longer online)
  2. UP, UP, UP: Terminology and Descriptions of Geneaological Words
  3. uP: Acronym Finder
  4. AbbreviationZ (No longer online)
  5. up: Idioms

Science (1 matching dictionary)
  1. up: LITTLE EXPLORERS(TM) Picture Dictionary

Slang (4 matching dictionaries)
  1. up, up, up, up, up, up: Green’s Dictionary of Slang
  2. up: English slang and colloquialisms used in the United Kingdom
  3. Up: Dublin Slang and Phrasebook
  4. U.P, up, the up: Urban Dictionary

Sports (4 matching dictionaries)
  1. Up: Dan's Poker
  2. Hickok Sports Glossaries (No longer online)
  3. Texas Hold'em Dictionary (No longer online)
  4. up: Golfer's Dictionary

Tech (2 matching dictionaries)
  1. UP: GEOGRAPHIC INFORMATION SYSTEMS, CARTOGRAPHY, AND REMOTE SENSING
  2. Paper Making (No longer online)

(Note: See uping as well.)

Definitions from Wiktionary (
)
American English Definition British English Definition
adverb:  Indicating movement towards or location at a higher place or position.
adverb:  Away from the surface of the Earth or other planet; in opposite direction to the downward pull of gravity.
adverb:  To or at a physically higher or more elevated position.
adverb:  To an upright or erect position.
adverb:  (figuratively) To a higher level of some quantity or notional quantity, such as price, volume, pitch, happiness, etc.
adverb:  Indicating movement in any other direction visualised as "up".
adverb:  To or towards what is considered the top of something, irrespective of whether this is presently physically higher.
adverb:  To the north (as north is at the top of typical maps).
adverb:  Towards or at a central place, or any place that is visualised as 'up' by virtue of local features or local convention, or arbitrarily, irrespective of direction or elevation change.
adverb:  (rail transport) Towards the principal terminus, towards milepost zero.
adverb:  (UK, academia, dated) To university, especially to Cambridge or Oxford.
adverb:  (sailing) Against the wind or current.
adverb:  (Cartesian graph) In a positive vertical direction.
adverb:  To or in a position of equal advance or equality; not short of, back of, less advanced than, away from, etc.; usually followed by to or with.
adverb:  (intensifier) Used as an aspect marker to indicate a completed action or state; thoroughly, completely.
adverb:  To or from one's possession or consideration.
adverb:  Aside or away, so as no longer to be present or in use.
adverb:  (cricket) Relatively close to the batsman.
adverb:  (US, bartending) Without additional ice.
adjective:  Facing upwards.
adjective:  On or at a physically higher level.
adjective:  Headed or designated to go upward (as an escalator, stairway, elevator etc.) or toward (as a run-up).
adjective:  Fitted or fixed at a high or relatively high position, especially on a wall or ceiling.
adjective:  (by extension) Available to view or use; made public; posted.
adjective:  Aloft.
adjective:  Raised; lifted.
adjective:  Built, constructed.
adjective:  Standing; upright.
adjective:  (obsolete) Risen up, rebelling, in revolt.
adjective:  Awake and out of bed.
adjective:  (horse-racing) Riding the horse; mounted.
adjective:  (of the sun or moon) Above the horizon, in the sky.
adjective:  Larger; greater in quantity, volume, value etc.
adjective:  Indicating a larger or higher quantity.
adjective:  Ahead; leading; winning.
adjective:  (predicative only) Finished, to an end
adjective:  In a good mood.
adjective:  (usually in the phrase up for) Willing; ready.
adjective:  Next in a sequence.
adjective:  (predicative only) Happening; new; of concern. See also what's up, what's up with.
adjective:  (poker, postnominal) Said of the higher-ranking pair in a two pair.
adjective:  Well-informed; current.
adjective:  (computing) Functional; working.
adjective:  (of a railway line or train) Traveling towards a major terminus.
adjective:  (US, bartending) Chilled and served without ice.
adjective:  (slang) Erect.
adjective:  (UK, dated) At university (especially Oxford or Cambridge).
adjective:  (slang, graffiti) well-known; renowned
noun:  (uncountable) The direction opposed to the pull of gravity.
noun:  (countable) A positive thing, or a time or situation when things are going well.
noun:  (particle physics) An up quark.
noun:  An upstairs room of a two story house.
verb:  (transitive, poetic or in certain phrases) To physically raise or lift.
verb:  (transitive, colloquial) To increase the level or amount of.
verb:  (transitive, colloquial) To promote.
verb:  (intransitive, often in combination with another verb) To rise to a standing position; hence, by extension, to act suddenly; see also up and.
verb:  (intransitive, archaic or poetic) To ascend; to climb up.
verb:  (computing, slang, transitive) To upload.
noun:  Initialism of Upper Peninsula. [The northern of the two peninsulas that make up the US state of Michigan.]
noun:  (religion) Initialism of United Presbyterian.
noun:  (India) Initialism of Uttar Pradesh. [A state in northern India. Capital: Lucknow.]
noun:  (software) Initialism of Unified Process.
noun:  (Philippines) Initialism of University of the Philippines.
noun:  Initialism of unqualified prospect. [A person or company that is a potential client for a sale, but who has not been previously vetted.]
noun:  Initialism of university press.

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