Usually means: Exhaust from physical or mental effort.
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We found 12 dictionaries that define the word tire out:

General (9 matching dictionaries)
  1. tire out: Vocabulary.com
  2. tire out: Wiktionary
  3. tire out: Dictionary.com
  4. tire out: Rhymezone
  5. tire out: Free Dictionary
  6. tire out: Mnemonic Dictionary
  7. tire out: Dictionary/thesaurus

Business (1 matching dictionary)
  1. tire out: Legal dictionary

Computing (1 matching dictionary)
  1. tire out: Encyclopedia

Miscellaneous (1 matching dictionary)
  1. tire out: Idioms

Definitions from Wiktionary (tire out)

verb:  To make someone tired; to exhaust.

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