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Definitions from Wiktionary ()
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▸ adjective: Having a noticeable or major effect.
▸ adjective: Reasonably large in number or amount.
▸ adjective: Having a covert or hidden meaning.
▸ adjective: (statistics) Having a low probability of occurring by chance (for example, having high correlation and thus likely to be related).
▸ adjective: (mathematics) Of a digit or figure, see significant figure.
▸ noun: That which has significance; a sign; a token; a symbol.
Similar:
meaningful,
considerable,
momentous,
portentous,
substantial,
world-shaking,
important,
remarkable,
noteworthy,
operative,
more...
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