Usually means: Disease causing widespread death, suffering.
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We found 46 dictionaries that define the word plague:

General (26 matching dictionaries)
  1. plague: Merriam-Webster.com
  2. plague, plague: Oxford Learner's Dictionaries
  3. plague: American Heritage Dictionary of the English Language
  4. plague: Collins English Dictionary
  5. plague: Vocabulary.com
  6. Plague, plague: Wordnik
  7. plague: Cambridge Advanced Learner's Dictionary
  8. plague, the plague: Wiktionary
  9. plague: Webster's New World College Dictionary, 4th Ed.
  10. plague: The Wordsmyth English Dictionary-Thesaurus
  11. plague: Infoplease Dictionary
  12. plague, the plague: Dictionary.com
  13. plague (n.): Online Etymology Dictionary
  14. plague: Cambridge Essential American English Dictionary
  15. Plague (disambiguation), Plague (disease), Plague (painting), Plague (song), Plague, Plague, The Plague (American band), The Plague (Brotha Lynch Hung album), The Plague (English band), The Plague (English punk rock band), The Plague (Father Ted), The Plague (New Zealand band), The Plague (Nuclear Assault EP), The Plague (band), The Plague (magazine), The Plague, The plague: Wikipedia, the Free Encyclopedia
  16. Plague: Online Plain Text English Dictionary
  17. plague: Webster's Revised Unabridged, 1913 Edition
  18. plague: Rhymezone
  19. plague: AllWords.com Multi-Lingual Dictionary
  20. plague: Webster's 1828 Dictionary
  21. plague: Free Dictionary
  22. plague: Mnemonic Dictionary
  23. plague: Dictionary/thesaurus
  24. plague: Wikimedia Commons US English Pronunciations

Business (1 matching dictionary)
  1. Plague (disambiguation), plague: Legal dictionary

Computing (1 matching dictionary)
  1. Plague (disambiguation), plague: Encyclopedia

Medicine (11 matching dictionaries)
  1. Dorland's Illustrated Medical Dictionary (No longer online)
  2. Plague: MedTerms.com Medical Dictionary
  3. Medical Dictionary (No longer online)
  4. Plague: Merck Manuals
  5. online medical dictionary (No longer online)
  6. Specific Diseases/Disorders (No longer online)
  7. Plague: MEDLINE plus Illustrated Medical Encyclopedia
  8. Plague (disambiguation), plague: Medical dictionary
  9. University of Maryland Glossary of Medical Terms (No longer online)
  10. Plague: Drug Medical Dictionary
  11. Hyperdictionary (No longer online)

Miscellaneous (4 matching dictionaries)
  1. Brilliant Dream Dictionary (No longer online)
  2. Plague, Plague, Plague: Terminology and Descriptions of Geneaological Words
  3. Glossary of Terrorism Terms (No longer online)
  4. plague: Idioms

Religion (1 matching dictionary)
  1. Plague: Easton Bible

Science (1 matching dictionary)
  1. Agricultural Thesaurus and Glossary (No longer online)

Slang (1 matching dictionary)
  1. The Plague, plague: Urban Dictionary

(Note: See plagued as well.)

Definitions from Wiktionary (
)
American English Definition British English Definition
noun:  (often used with the, sometimes capitalized: the Plague) The bubonic plague, the pestilent disease caused by the virulent bacterium Yersinia pestis.
noun:  (pathology) An epidemic or pandemic caused by any pestilence, but specifically by the above disease.
noun:  A widespread affliction, calamity, or destructive influx, especially when seen as divine retribution.
noun:  (figurative) A grave nuisance, whatever greatly irritates.
noun:  (ornithology) A group of common grackles.
verb:  (transitive) To harass, pester or annoy someone persistently or incessantly.
verb:  (transitive) To afflict with a disease or other calamity.

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