Usually means: Remove someone from a base.
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We found 18 dictionaries that define the word pick off:

General (13 matching dictionaries)
  1. pick off: Merriam-Webster.com
  2. pick off: Collins English Dictionary
  3. pick-off, pick off: Vocabulary.com
  4. pick-off: Wordnik
  5. pick off: Wiktionary
  6. pick-off: Infoplease Dictionary
  7. pick-off, pick off: Dictionary.com
  8. pick off: Rhymezone
  9. pick-off, pick off: Free Dictionary
  10. pick-off, pick off: Mnemonic Dictionary
  11. pick-off, pick off: Dictionary/thesaurus

Business (1 matching dictionary)
  1. pick off: Legal dictionary

Computing (1 matching dictionary)
  1. pick off: Encyclopedia

Medicine (1 matching dictionary)
  1. pick off: Medical dictionary

Miscellaneous (1 matching dictionary)
  1. pick off: Idioms

Tech (1 matching dictionary)
  1. pick off: Coin Collecting

Definitions from Wiktionary (pick off)

verb:  (literally) To remove by picking.
verb:  To dispose of tasks, obstacles, opponents etc. precisely, one by one.
verb:  To shoot one by one.
verb:  (baseball) To throw out a runner by tagging them whilst they are not in contact with any of the three bases or home plate.
verb:  To intercept, such as a ball in flight.
noun:  (baseball) An instance of throwing out a batter leading off base.

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