Usually means: Nuclear weapon with massive destruction.
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We found 35 dictionaries that define the word nuke:

General (22 matching dictionaries)
  1. nuke: Longman Dictionary of Contemporary English
  2. nuke: Merriam-Webster
  3. nuke: Oxford Learner's Dictionaries
  4. nuke: American Heritage Dictionary of the English Language
  5. nuke: Collins English Dictionary
  6. nuke: Vocabulary.com
  7. Nuke, nuke: Wordnik
  8. nuke: Cambridge Advanced Learner's Dictionary
  9. nuke: Wiktionary
  10. nuke: Webster's New World College Dictionary, 4th Ed.
  11. nuke: Infoplease Dictionary
  12. nuke: Dictionary.com
  13. nuke: Online Etymology Dictionary
  14. nuke: Cambridge Essential American English Dictionary
  15. Nuke (Marvel Comics), Nuke (Squadron Supreme), Nuke (computer), Nuke (gaming), Nuke (software), Nuke (video games), Nuke (warez), Nuke: Wikipedia, the Free Encyclopedia
  16. nuke: Rhymezone
  17. nuke: FreeDictionary.org
  18. nuke: ESL Idiom Page
  19. nuke: Mnemonic Dictionary
  20. nuke: TheFreeDictionary.com

Computing (3 matching dictionaries)
  1. nuke: Free On-line Dictionary of Computing
  2. nuke: Hacking Lexicon
  3. nuke: Encyclopedia

Medicine (3 matching dictionaries)
  1. AIDSinfo Glossary (No longer online)
  2. online medical dictionary (No longer online)
  3. nuke: Medical dictionary

Miscellaneous (2 matching dictionaries)
  1. NUKE: Acronym Finder
  2. AbbreviationZ (No longer online)

Slang (5 matching dictionaries)
  1. nuke, nuke, nuke: Green’s Dictionary of Slang
  2. nuke: English slang and colloquialisms used in the United Kingdom
  3. American-Australian Slang Dictionary (No longer online)
  4. nuke: ESL Slang page
  5. The Nuke: Urban Dictionary

(Note: See nuked as well.)

Definitions from Wiktionary (
)
American English Definition British English Definition
noun:  A nuclear weapon.
noun:  (by extension) Something that destroys or negates, especially on a catastrophic scale.
noun:  A nuclear power station.
noun:  (nautical) A vessel such as a ship or submarine running on nuclear power.
noun:  A person (such as a sailor in a navy or a scientist) who works with nuclear weapons or nuclear power.
noun:  (warez) A cautionary flag placed on a release to label it as "bad" for some reason or another (e.g., being a dupe of a previous release or containing malware).
noun:  (rare) A microwave oven.
verb:  (transitive, chiefly US, colloquial) To use a nuclear weapon on a target.
verb:  (transitive, chiefly US, colloquial, figuratively) To destroy or erase completely.
verb:  (transitive, Internet slang, by extension) To carry out a denial-of-service attack against (an IRC user).
verb:  (transitive, chiefly US, colloquial) To expose to some form of radiation.
verb:  (transitive, chiefly US, colloquial) To cook in a microwave oven.
verb:  (transitive, US, nautical, colloquial) To overanalyze or despair unduly over something.
noun:  Alternative spelling of nuc (“nucleus colony of bees”) [(beekeeping) A nucleus colony; a small bee colony created from a larger colony.]
noun:  (anatomy, obsolete) Alternative form of nucha (“spinal cord; nape of the neck”) [(anatomy, obsolete) The spinal cord.]
noun:  (chiefly Northern England, archaic) Alternative form of nook (“a corner of a piece of land; an angled piece of land, especially one extending into other land”) [A small corner formed by two walls; an alcove.]

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