Usually means: Primary, chief, or most important.
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We found 45 dictionaries that define the word main:

General (27 matching dictionaries)
  1. Main, main: Merriam-Webster.com
  2. Main, main, main, the main: Oxford Learner's Dictionaries
  3. Main, main: American Heritage Dictionary of the English Language
  4. main: Collins English Dictionary
  5. main: Vocabulary.com
  6. Main, main: Wordnik
  7. main: Cambridge Advanced Learner's Dictionary
  8. Main, main: Wiktionary
  9. main: Webster's New World College Dictionary, 4th Ed.
  10. main: The Wordsmyth English Dictionary-Thesaurus
  11. main: Infoplease Dictionary
  12. Main, main: Dictionary.com
  13. main (adj.), main (n.): Online Etymology Dictionary
  14. main: Cambridge Essential American English Dictionary
  15. Ma'in, Main (CTA Niles Center station), Main (band), Main (cigarette), Main (river), Main (surname), Main, The Main: Wikipedia, the Free Encyclopedia
  16. Main: Online Plain Text English Dictionary
  17. main: Webster's Revised Unabridged, 1913 Edition
  18. main: Rhymezone
  19. main, main (f): AllWords.com Multi-Lingual Dictionary
  20. main: Webster's 1828 Dictionary
  21. main: Free Dictionary
  22. main: The Phrontistery - A Dictionary of Obscure Words
  23. main: Mnemonic Dictionary
  24. Main: Dictionary/thesaurus
  25. main: Wikimedia Commons US English Pronunciations

Art (1 matching dictionary)
  1. Virginia Tech Multimedia Music Dictionary (No longer online)

Business (2 matching dictionaries)
  1. Construction Term Glossary (No longer online)
  2. Main (river, Germany), main: Legal dictionary

Computing (2 matching dictionaries)
  1. main: Free On-line Dictionary of Computing
  2. Main (river, Germany), main: Encyclopedia

Medicine (2 matching dictionaries)
  1. Dorland's Illustrated Medical Dictionary (No longer online)
  2. online medical dictionary (No longer online)

Miscellaneous (4 matching dictionaries)
  1. Sound-Alike Words (No longer online)
  2. MAIN: Acronym Finder
  3. AbbreviationZ (No longer online)
  4. main: Idioms

Slang (3 matching dictionaries)
  1. main, main, main, main: Green’s Dictionary of Slang
  2. main: The Folk File
  3. Ma'in, main: Urban Dictionary

Sports (1 matching dictionary)
  1. Main: Skydiving Glossary

Tech (3 matching dictionaries)
  1. AUTOMOTIVE TERMS (No longer online)
  2. Lake and Water Word Glossary (No longer online)
  3. SeaTalk Dictionary of English Nautical Language (No longer online)

(Note: See maining as well.)

Definitions from Wiktionary (
)
American English Definition British English Definition
adjective:  Of chief or leading importance; prime, principal.
adjective:  Chief, most important, or principal in extent, size, or strength; consisting of the largest part.
adjective:  (archaic, of force, strength, etc.) Full, sheer, undivided.
adjective:  (dialectal) Big; angry.
adjective:  (nautical) Belonging to or connected with the principal mast in a vessel.
adjective:  (obsolete) Great in size or degree; important, powerful, strong, vast.
adverb:  (British, dialectal) Exceedingly, extremely, greatly, mightily, very, very much.
verb:  (transitive, gaming) To mainly play a specific character or side, or with specific equipment, during a game.
verb:  (obsolete) To convert (a road) into a main or primary road.
noun:  (not in generic modern use) That which is chief or principal; the chief or main portion; the bulk, the greater part, gross.
noun:  (video games) The primary character that one plays in a video game in which one can play more than one character.
noun:  A large cable or pipe providing utility service to an area or a building, such as a water main or electric main.
noun:  (now poetic) The high seas.
noun:  (now archaic, US dialectal) The mainland.
noun:  (obsolete, except in might and main) Force, power, strength, violent effort.
noun:  (obsolete, gaming) A hand or match in a game of dice.
noun:  (obsolete, gaming) The largest throw in a match at dice; in the game of hazard, a number from one to nine called out by a person before the dice are thrown.
noun:  (obsolete, gaming) A stake played for at dice.
noun:  (obsolete, gaming, sports) A sporting contest or match, especially a cockfighting match.
noun:  A banker's shovel for coins.
noun:  (obsolete, rare) A basket for gathering grapes.
noun:  A river in southern Germany, flowing from Bavaria to the Rhine.
noun:  A river in Northern Ireland, flowing into Lough Neagh.
noun:  A surname.
verb:  (transitive, slang) Short for mainline (“to inject (a drug) directly into a vein”). [(slang) To inject (a drug) directly into a vein.]
noun:  (informal) Short for main course (“the principal dish of a meal”). [The main serving or dish of a meal, usually cooked.]
noun:  (nautical) Short for mainsail. [(nautical) The largest (or only) sail on a sailing vessel.]
noun:  Ellipsis of Main Street.: A street named "Main Street". [The generic street name (and often the official name) of the primary retail street of a village, town, or small city in the United States, Canada, Ireland, some parts of Scotland and also in some countries in central Europe.]
noun:  Ellipsis of Main Street (“main street”).: A central street of a community [The generic street name (and often the official name) of the primary retail street of a village, town, or small city in the United States, Canada, Ireland, some parts of Scotland and also in some countries in central Europe.]

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