Usually means: Minimizing sum of squared differences.
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We found 21 dictionaries that define the word least squares:

General (14 matching dictionaries)
  1. least squares: Merriam-Webster
  2. least squares: Oxford Learner's Dictionaries
  3. least squares: American Heritage Dictionary of the English Language
  4. least squares: Collins English Dictionary
  5. least squares: Vocabulary.com
  6. least-squares: Wordnik
  7. least squares: Wiktionary
  8. least squares: Infoplease Dictionary
  9. Least squares, least squares: Dictionary.com
  10. Least-squares, Least squares (function approximation), Least squares: Wikipedia, the Free Encyclopedia
  11. least squares: Rhymezone
  12. least squares: FreeDictionary.org
  13. least squares: Mnemonic Dictionary
  14. least squares: TheFreeDictionary.com

Computing (1 matching dictionary)
  1. least squares: Encyclopedia

Medicine (2 matching dictionaries)
  1. online medical dictionary (No longer online)
  2. Least-squares, least squares: Medical dictionary

Science (3 matching dictionaries)
  1. Agricultural Thesaurus and Glossary (No longer online)
  2. least-squares, least squares: PlanetMath Encyclopedia
  3. Statistics (No longer online)

Tech (1 matching dictionary)
  1. Glossary of Meteorology (No longer online)

Definitions from Wiktionary (least squares)

noun:  (mathematics) A method of fitting a straight line through a series of points such that the sum of the squares of the residuals is minimized

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