Usually means: Severe mental illness, impaired reasoning.
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Similar:
maniacal, idiotic, wacky, crazy, foolish, mad, crazed, lunatic, berserk, barmy, more...

Opposite:
sane, rational, lucid, balanced, stable

Meter:

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Adjectives:
criminal, semi, indigent, total, dangerous, incurable, tuberculous, become, least

Crossword clues:
wild and crazy,   mentally unstable,   drive crazy,   totally mad,   totally crazy,   mentally unwell,   more crazy,   lost your mind,   out of ones mind,   bat shit crazy

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