eminent, remarkable, noteworthy, of the essence, valuable, significant, crucial, distinguished, historic, cardinal, more...

trivial, insignificant, negligible, minor, inconsequential

most, very, least, all, highly, unimportant, how, yourself, some, self, quite

most significant,   key factor,   means a lot,   don't miss,   very significant,   what matters,   of concern,   note worthy,   special to me,   you matter