Sorry, no online dictionaries contain the exact phrase harmful substance.
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Reverse dictionary results:
1. toxin
2. addiction
3. antibody
4. pesticide
5. poison
6. poisoned
7. poisoning
8. sweeten
9. contaminate
10. affect
11. bait
12. cure
13. cured
14. detoxify
15. disinfectant
16. expose
17. foul
18. fume
19. fumes
20. infection
21. nait
22. severe
23. stong
24. strong
25. toxic
26. toxics
27. toxins
28. urine
29. negatively
30. antidote
31. antiseptic
32. corrosive
33. lindane
34. measure
35. resistance
36. abuser
37. accident
38. black
39. septic
40. addict

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You can look up the words in the phrase individually using these links:   harmful ?   substance ?
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