Usually means: Distress due to gender mismatch.
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We found 12 dictionaries that define the word gender dysphoria:

General (6 matching dictionaries)
  1. gender dysphoria: Merriam-Webster
  2. gender dysphoria: Oxford Learner's Dictionaries
  3. gender dysphoria: Collins English Dictionary
  4. gender dysphoria: Wiktionary
  5. Gender Dysphoria, Gender dysphoria: Wikipedia, the Free Encyclopedia
  6. gender dysphoria: TheFreeDictionary.com

Computing (1 matching dictionary)
  1. gender dysphoria: Encyclopedia

Medicine (4 matching dictionaries)
  1. gender dysphoria: Merriam-Webster Medical Dictionary
  2. Dorland's Illustrated Medical Dictionary (No longer online)
  3. Terms in the field of Psychiatry and Neurology (No longer online)
  4. gender dysphoria: Medical dictionary

Miscellaneous (1 matching dictionary)
  1. Glossary of Unusual Sexual Practices (No longer online)

Definitions from Wiktionary (gender dysphoria)

noun:  A profound and persistent unhappiness caused by having characteristics (body parts, clothing, etc) of, or being perceived as, a gender different from one's gender identity, experienced especially by transgender people.

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