Usually means: Ending a romantic relationship permanently.
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We found 28 dictionaries that define the word break up:

General (19 matching dictionaries)
  1. break up: Merriam-Webster.com
  2. break up: Oxford Learner's Dictionaries
  3. break-up, break-up, break up: Collins English Dictionary
  4. break up: Vocabulary.com
  5. Break-Up, Break-up, break-up: Wordnik
  6. break-up, break (sth) up, break up: Cambridge Advanced Learner's Dictionary
  7. break-up, break up: Wiktionary
  8. Break-up, break up: Dictionary.com
  9. Break-Up, Break Up (Bye Bye), Break Up (Mario song), Break Up (album), Break Up (disambiguation), Break Up (song), Break Up, Break-up, Break up, The Break_Up (Glee), The Break-Up, The Break Up, The Break-up: Wikipedia, the Free Encyclopedia
  10. Break-up: Online Plain Text English Dictionary
  11. break-up: Webster's Revised Unabridged, 1913 Edition
  12. break up: Rhymezone
  13. break-up, break up: AllWords.com Multi-Lingual Dictionary
  14. break up: Phrasal Verb Page
  15. break-up, break up: Free Dictionary
  16. break up: Mnemonic Dictionary
  17. break-up, break up: Dictionary/thesaurus

Business (3 matching dictionaries)
  1. MoneyGlossary.com (No longer online)
  2. break up: Legal dictionary
  3. break up: Financial dictionary

Computing (1 matching dictionary)
  1. break up: Encyclopedia

Medicine (1 matching dictionary)
  1. break up: Medical dictionary

Miscellaneous (1 matching dictionary)
  1. break up: Idioms

Slang (2 matching dictionaries)
  1. break up: Green’s Dictionary of Slang
  2. the break up: Urban Dictionary

Tech (1 matching dictionary)
  1. AUTOMOTIVE TERMS (No longer online)

(Note: See break_ups as well.)

Definitions from Wiktionary (break up)

verb:  (transitive) To break or separate into pieces.
verb:  (intransitive) To break or separate into pieces; to disintegrate or come apart.
verb:  (transitive) To upset greatly; to cause great emotional disturbance or unhappiness in.
verb:  (intransitive, idiomatic) To end a (usually romantic or sexual) relationship.
verb:  (reciprocal, intransitive) To end a (usually romantic or sexual) relationship with each other.
verb:  (intransitive, idiomatic) To dissolve; to part.
verb:  (intransitive, idiomatic) Of a school, to close for the holidays at the end of term.
verb:  (intransitive, telecommunications) Of a conversation, to cease to be understandable because of a bad connection; of a signal, to deteriorate.
verb:  (transitive, idiomatic) To stop a fight; to separate people who are fighting.
verb:  (intransitive, idiomatic, figuratively) To become disorganised.
verb:  (transitive) To cut or take to pieces for scrap.
verb:  (transitive, intransitive, idiomatic, slang) To be or cause to be overcome with laughter.
noun:  Alternative form of breakup [The act of breaking up; disintegration or division.]

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