Usually means: Significant, impactful change or idea.
Definitions Related words Mentions
We found 14 dictionaries that define the word big C:

General (8 matching dictionaries)
  1. big C: Merriam-Webster
  2. the Big C, the Big C: Oxford Learner's Dictionaries
  3. big C: American Heritage Dictionary of the English Language
  4. big C: Wiktionary
  5. Big C: Infoplease Dictionary
  6. Big C, big c: Dictionary.com
  7. Big C (fight song), Big C, The Big C (TV series), The Big C, The Big C: Wikipedia, the Free Encyclopedia
  8. big C: TheFreeDictionary.com

Business (1 matching dictionary)
  1. big C: Financial dictionary

Computing (1 matching dictionary)
  1. big C: Encyclopedia

Medicine (1 matching dictionary)
  1. big C: Medical dictionary

Slang (3 matching dictionaries)
  1. big C, Big C: Green’s Dictionary of Slang
  2. Big C: Street Terms: Drugs and the Drug Trade
  3. big c, the big c: Urban Dictionary

Definitions from Wiktionary (big C)

noun:  (slang, euphemistic) cancer.

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