Usually means: Shun intensely to prevent harm.
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We found 4 dictionaries that define the word avoid like the plague:

General (2 matching dictionaries)
  1. avoid like the plague: Merriam-Webster
  2. avoid like the plague: Wiktionary

Miscellaneous (1 matching dictionary)
  1. avoid like the plague: Idioms

Slang (1 matching dictionary)
  1. avoid like the plague: Urban Dictionary

Definitions from Wiktionary (avoid like the plague)

verb:  (simile) To evade or shun, if at all possible.

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Words similar to avoid like the plague

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