sour, bitter, acerb, acid, acrid, caustic, blistering, venomous, vitriolic, virulent, more...

sweet, mild, gentle, tame, tolerant, forgiving, bland, tepid, mellow, soft

annoyed tone,   harsh tone,   in a sour mood,   sharp tone,   hurt tone,   say burning caustic,   bitterly sarcastic,   sharp personality,   maximally waspish,   sharp sarcasm