Usually means: Make a significant, damaging mistake.
Definitions Related words Phrases Mentions Lyrics
We found 21 dictionaries that define the word fuck up:

General (16 matching dictionaries)
  1. fuck up: Merriam-Webster
  2. fuck-up: Oxford Learner's Dictionaries
  3. fuck-up, fuck up: Collins English Dictionary
  4. fuck up: Vocabulary.com
  5. fuck-up, fuck (sth) up: Cambridge Advanced Learner's Dictionary
  6. fuck-up, fuck up: Wiktionary
  7. fuck up: Dictionary.com
  8. fuck-up: Cambridge Essential American English Dictionary
  9. Fuck Up: Wikipedia, the Free Encyclopedia
  10. fuck up: Rhymezone
  11. fuck up: FreeDictionary.org
  12. fuck up: Mnemonic Dictionary
  13. fuck-up, fuck up: TheFreeDictionary.com
  14. fuck up: Longman Dictionary of Contemporary English

Computing (1 matching dictionary)
  1. fuck up: Encyclopedia

Miscellaneous (1 matching dictionary)
  1. fuck up: Idioms

Slang (3 matching dictionaries)
  1. fuck up: Green’s Dictionary of Slang
  2. fuck up: English slang and colloquialisms used in the United Kingdom
  3. the fuck up: Urban Dictionary

(Note: See fuck_ups as well.)

Definitions from Wiktionary (fuck up)

verb:  (intransitive, slang, vulgar) To make a mistake, to go wrong.
verb:  (transitive, vulgar) To botch or make a mess of.
verb:  (transitive, vulgar) To injure or damage badly.
verb:  (vulgar) To cause someone to become intoxicated or otherwise alter someone's mental state.
verb:  (vulgar) To traumatise; to negatively affect the wellbeing of someone.
verb:  (used only in imperative, vulgar) Ellipsis of shut the fuck up.
noun:  Alternative spelling of fuckup [(vulgar) A serious mistake.]

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