Usually means: Dejected, impoverished, or in despair.
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We found 20 dictionaries that define the word down and out:

General (18 matching dictionaries)
  1. down-and-out: Merriam-Webster
  2. down-and-out: Oxford Learner's Dictionaries
  3. down-and-out: American Heritage Dictionary of the English Language
  4. down-and-out, down-and-out: Collins English Dictionary
  5. down-and-out: Vocabulary.com
  6. down-and-out: Wordnik
  7. down-and-out: Cambridge Advanced Learner's Dictionary
  8. down-and-out, down and out: Wiktionary
  9. down-and-out: Infoplease Dictionary
  10. down-and-out, down and out: Dictionary.com
  11. Down and Out (Cam'ron song), Down and Out (George Strait song), Down and Out (film): Wikipedia, the Free Encyclopedia
  12. down-and-out: Rhymezone
  13. down-and-out: FreeDictionary.org
  14. down-and-out: Mnemonic Dictionary
  15. down-and-out, down and out: TheFreeDictionary.com
  16. down and out: Longman Dictionary of Contemporary English

Business (1 matching dictionary)
  1. Comprehensive Financial (No longer online)

Slang (1 matching dictionary)
  1. down-and-out, down and out: Urban Dictionary

Definitions from Wiktionary (down and out)

adjective:  (idiomatic) In a condition of poverty or debility, especially as a result of experiencing a financial or personal setback.
noun:  Synonym of down-and-outer.

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