Usually means: "You" in informal, casual communication.
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We found 15 dictionaries that define the word U:

General (5 matching dictionaries)
  1. u: Longman Dictionary of Contemporary English
  2. u: Merriam-Webster
  3. -u-, u-: Wiktionary
  4. u-: Dictionary.com
  5. The U (documentary), The U (film), The U, 'U' (opera), U(1), U(N), U (Cyrillic), U (Kendrick Lamar song), U (Super Junior song), U (TV channel), U (album), U (cuneiform), U (disambiguation), U (kana), 'u' (opera): Wikipedia, the Free Encyclopedia

Computing (1 matching dictionary)
  1. U(n): Encyclopedia

Medicine (3 matching dictionaries)
  1. U: Merriam-Webster Medical Dictionary
  2. U (uracil): MedTerms.com Medical Dictionary
  3. U (uracil): Drug Medical Dictionary

Miscellaneous (1 matching dictionary)
  1. AbbreviationZ (No longer online)

Science (2 matching dictionaries)
  1. U-: A Dictionary of Quaternary Acronyms and Abbreviations
  2. How Many? A Dictionary of Units of Measurement (No longer online)

Slang (3 matching dictionaries)
  1. U: Green’s Dictionary of Slang
  2. The U: A Seattle Lexicon
  3. the u: Urban Dictionary

(Note: See u's as well.)

Definitions from Wiktionary (U)

noun:  The name of the Latin-script letter U/u.
noun:  A thing in the shape of the letter U
noun:  A U-turn.
noun:  (UK) A film with the film classification U (“universal”).
adjective:  (not comparable, education, espionage) Usually in parentheses: abbreviation of unclassified.
adjective:  (not comparable, UK) In a film certificate: abbreviation of universal (“suitable for all ages”).
noun:  A language belonging to the Austroasiatic language family which is spoken in China.
noun:  An honorific to a Burmese man
adjective:  Abbreviation of underwater. [(not comparable) Beneath the surface of the water; of or pertaining to the region beneath the water surface.]
noun:  Abbreviation of university. [Institution of higher education (typically accepting students from the age of about 17 or 18, depending on country, but in some exceptional cases able to take younger students) where subjects are studied and researched in depth and degrees are offered.]
noun:  Abbreviation of Sunday. [The first day of the week in many religious traditions, and the seventh day of the week in systems using the ISO 8601 standard; the Christian Sabbath; the Lord's Day; it follows Saturday and precedes Monday.]
adjective:  (comparable, chiefly British, dated) Abbreviation of upper class (“characteristic of the upper classes, particularly in the use of language”).
adjective:  (not comparable) Abbreviation of united. [Joined into a single entity.]
adjective:  (not comparable) Abbreviation of upper. [At a higher level, rank or position.]
noun:  Alternative form of Ü (“Tibetan language”) [(uncommon) The Central Tibetan language, a variety of Tibetan.]

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