Might mean (unverified): Alkaloid found in some plants.
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We found 2 dictionaries that define the word columbamine:

General (2 matching dictionaries)
  1. columbamine: Merriam-Webster
  2. columbamine: Wiktionary

Definitions from Wiktionary (columbamine)

noun:  (organic chemistry) A quaternary isoquinoline alkaloid isolated from Argemone mexicana, (Mexican poppy).

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