Usually means: Producing many offspring or ideas.
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We found 3 dictionaries that define the word polyphiloprogenitive:

General (3 matching dictionaries)
  1. polyphiloprogenitive: Merriam-Webster
  2. polyphiloprogenitive: Wiktionary
  3. polyphiloprogenitive: The Phrontistery - A Dictionary of Obscure Words

Definitions from Wiktionary (polyphiloprogenitive)

adjective:  (very rare) Having many descendants.

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