Usually means: Slang term for inexperienced, naive person.
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We found 15 dictionaries that define the word Opie:

General (11 matching dictionaries)
  1. Opie, opie: Wordnik
  2. OPIE, Opie: Dictionary.com
  3. OPIE (Entomology), Opie (Family Guy), Opie (name), Opie: Wikipedia, the Free Encyclopedia
  4. Opie: Online Plain Text English Dictionary
  5. opie: Webster's Revised Unabridged, 1913 Edition
  6. Opie: Rhymezone
  7. Opie: AllWords.com Multi-Lingual Dictionary
  8. OPIE: Stammtisch Beau Fleuve Acronyms
  9. opie: FreeDictionary.org
  10. Opie: TheFreeDictionary.com
  11. Opie: Wiktionary

Computing (1 matching dictionary)
  1. OPIE: Encyclopedia

Miscellaneous (1 matching dictionary)
  1. OPIE: Acronym Finder

Slang (2 matching dictionaries)
  1. Opie (offensive): Racial Slur Database
  2. Opie: Urban Dictionary

Definitions from Wiktionary (Opie)

noun:  A surname from Cornish.

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