Usually means: Treat someone in a harsh manner.
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We found 16 dictionaries that define the word rough up:

General (12 matching dictionaries)
  1. rough up: Longman Dictionary of Contemporary English
  2. rough up: Merriam-Webster
  3. rough up: Collins English Dictionary
  4. rough up: Vocabulary.com
  5. rough up: Wiktionary
  6. rough up: Dictionary.com
  7. rough up: Rhymezone
  8. rough up: FreeDictionary.org
  9. rough up: Mnemonic Dictionary
  10. rough up: TheFreeDictionary.com

Business (1 matching dictionary)
  1. rough up: Legal dictionary

Computing (1 matching dictionary)
  1. rough up: Encyclopedia

Miscellaneous (1 matching dictionary)
  1. rough up: Idioms

Slang (1 matching dictionary)
  1. rough up: Green’s Dictionary of Slang

Definitions from Wiktionary (rough up)

verb:  to manhandle or beat up
verb:  To make rough, to roughen (especially doing so to wood while raising the grain)

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