Usually means: Person who frequently vomits excessively.
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We found 14 dictionaries that define the word puker:

General (12 matching dictionaries)
  1. puker: Merriam-Webster
  2. puker: Collins English Dictionary
  3. puker: Wordnik
  4. puker: Wiktionary
  5. Puker: Dictionary.com
  6. Puker: Wikipedia, the Free Encyclopedia
  7. Puker: Online Plain Text English Dictionary
  8. puker: Webster's Revised Unabridged, 1913 Edition
  9. Puker: AllWords.com Multi-Lingual Dictionary
  10. puker: Webster's 1828 Dictionary
  11. puker: FreeDictionary.org
  12. Puker: TheFreeDictionary.com

Slang (2 matching dictionaries)
  1. puker: Green’s Dictionary of Slang
  2. puker: Urban Dictionary

Definitions from Wiktionary (puker)

noun:  Someone who pukes, a vomiter.
noun:  That which causes vomiting.
noun:  (broadcasting, slang) A person who caricatures the manner of speech of a disc jockey or announcer, using affected, back-of-the-throat speech that is likened to puking.
noun:  (slang, derogatory) A detestable person.

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