Usually means: Younger female sibling, often cherished.
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We found 10 dictionaries that define the word little sister:

General (9 matching dictionaries)
  1. little sister: Merriam-Webster
  2. little sister: Vocabulary.com
  3. little sister: Wiktionary
  4. little sister: Dictionary.com
  5. Little Sister (Elvis Presley song), Little Sister (band), Little Sister (song), Little Sister, The Little Sister: Wikipedia, the Free Encyclopedia
  6. little sister: Rhymezone
  7. little sister: FreeDictionary.org
  8. little sister: Mnemonic Dictionary
  9. little sister: TheFreeDictionary.com

Slang (1 matching dictionary)
  1. Little Sister: Urban Dictionary

(Note: See little_sisters as well.)

Definitions from Wiktionary (little sister)

noun:  (informal) Synonym of younger sister

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