Usually means: Hold dominant position over others.
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We found 6 dictionaries that define the word reign supreme:

General (6 matching dictionaries)
  1. reign supreme: Longman Dictionary of Contemporary English
  2. reign supreme: Merriam-Webster
  3. Reign Supreme: Wikipedia, the Free Encyclopedia
  4. reign supreme: Wiktionary

Definitions from Wiktionary (reign supreme)

verb:  (idiomatic) To be the most important or most prevalent.

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