Might mean (unverified): Winning four bets in succession.
Definitions Related words Mentions
We found 2 dictionaries that define the word quadfecta:

General (1 matching dictionary)
  1. quadfecta: Wiktionary

Slang (1 matching dictionary)
  1. quadfecta: Urban Dictionary

Definitions from Wiktionary (quadfecta)

noun:  (gambling, horse racing) A bet in which the bettor must select the winners of the first four places (i.e., first, second, third, and fourth) of a race in the correct order.
noun:  (by extension) A set of four wins at related events; a set of four events.

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