Usually means: Vulgar slang for extremely contemptible person.
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We found 3 dictionaries that define the word muthafucka:

General (2 matching dictionaries)
  1. muthafucka: Wiktionary
  2. Muthafucka (song): Wikipedia, the Free Encyclopedia

Slang (1 matching dictionary)
  1. muthafucka: Green’s Dictionary of Slang

Definitions from Wiktionary (muthafucka)

noun:  (vulgar, offensive, African-American Vernacular) motherfucker

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