Usually means: Smegma found under the foreskin.
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We found 5 dictionaries that define the word knob cheese:

General (1 matching dictionary)
  1. knob cheese: Wiktionary

Computing (1 matching dictionary)
  1. Knob cheese: Encyclopedia

Medicine (1 matching dictionary)
  1. Knob cheese: Medical dictionary

Slang (2 matching dictionaries)
  1. knob cheese (!): English slang and colloquialisms used in the United Kingdom
  2. Knob-Cheese, Knob Cheese, knob-cheese (fromage a la cock): Urban Dictionary

Definitions from Wiktionary (knob cheese)

noun:  (vulgar, slang) Smegma which is secreted between the glans penis and foreskin.

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