Usually means: Slang: emits loud, explosive flatulence.
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We found 11 dictionaries that define the word guffer:

General (9 matching dictionaries)
  1. guffer: Merriam-Webster
  2. guffer: Wordnik
  3. guffer: Wiktionary
  4. guffer: Dictionary.com
  5. Guffer: Online Plain Text English Dictionary
  6. guffer: Webster's Revised Unabridged, 1913 Edition
  7. Guffer: AllWords.com Multi-Lingual Dictionary
  8. guffer: FreeDictionary.org
  9. Guffer: TheFreeDictionary.com

Medicine (1 matching dictionary)
  1. online medical dictionary (No longer online)

Slang (1 matching dictionary)
  1. guffer: Urban Dictionary

Definitions from Wiktionary (guffer)

noun:  The eelpout
noun:  A farter; someone who farts

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