Usually means: Total party kill in gaming.
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We found 14 dictionaries that define the word TPK:

General (10 matching dictionaries)
  1. tpk: Merriam-Webster
  2. tpk: Oxford Learner's Dictionaries
  3. Tpk: American Heritage Dictionary of the English Language
  4. Tpk: Wordnik
  5. TPK, Tpk: Wiktionary
  6. tpk: Webster's New World College Dictionary, 4th Ed.
  7. tpk: Infoplease Dictionary
  8. TPK, Tpk, tpk: Dictionary.com
  9. TPK: Wikipedia, the Free Encyclopedia
  10. Tpk: TheFreeDictionary.com

Miscellaneous (2 matching dictionaries)
  1. TPK: Acronym Finder
  2. AbbreviationZ (No longer online)

Science (1 matching dictionary)
  1. TPK: A Dictionary of Quaternary Acronyms and Abbreviations

Slang (1 matching dictionary)
  1. TPK: Urban Dictionary

Definitions from Wiktionary (Tpk)

noun:  (roleplaying games) Initialism of total party kill: the situation where all of the player characters in a role-playing game have been killed.
noun:  Abbreviation of turnpike. [A frame consisting of two bars crossing each other at right angles and turning on a post or pin, to hinder the passage of animals, but admitting a person to pass between the arms; a turnstile.]

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