Usually means: International Space Station orbiting laboratory.
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We found 22 dictionaries that define the word ISS:

General (8 matching dictionaries)
  1. iss: Merriam-Webster
  2. IS's, Iss, is's, iss: Wordnik
  3. ISS: Wiktionary
  4. ISS, iss: Dictionary.com
  5. ISS (disambiguation), ISS, Iss: Wikipedia, the Free Encyclopedia
  6. I.S.S, ISS, Iss: Stammtisch Beau Fleuve Acronyms
  7. ISS: TheFreeDictionary.com
  8. ISS: Collins English Dictionary

Art (1 matching dictionary)
  1. ODLIS: Online Dictionary of Library and Information Science (No longer online)

Business (1 matching dictionary)
  1. ISS: Financial dictionary

Computing (4 matching dictionaries)
  1. ISS: Netlingo
  2. ISS: CCI Computer
  3. SMS Dictionary (No longer online)
  4. ISS: Encyclopedia

Medicine (1 matching dictionary)
  1. ISS: Medical dictionary

Miscellaneous (3 matching dictionaries)
  1. ISS: Acronym Finder
  2. AbbreviationZ (No longer online)
  3. United States Postal Service Official Abbreviations (No longer online)

Science (1 matching dictionary)
  1. ISS: A Dictionary of Quaternary Acronyms and Abbreviations

Slang (1 matching dictionary)
  1. I.S.S, iss: Urban Dictionary

Tech (2 matching dictionaries)
  1. AUTOMOTIVE TERMS (No longer online)
  2. DOD Dictionary of Military Terms: Joint Acronyms and Abbreviations (No longer online)

Definitions from Wiktionary (ISS)

noun:  (education) Initialism of in-school suspension. [(education) A type of primary and secondary school suspension method in which, for a given period of time, the students being punished are not allowed to go to their regular classes, but are still required to attend school to instead be kept in an alternative setting that usually involves immobility and the performing of school-related activities.]
noun:  (space science) Initialism of International Space Station. [An artificial satellite in low-earth orbit operating by a number of cooperating space programs.]

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