Usually means: Drilling hole in skull surgically.
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We found 29 dictionaries that define the word trepan:

General (22 matching dictionaries)
  1. trepan: Merriam-Webster
  2. trepan: Oxford Learner's Dictionaries
  3. trepan, trepan: American Heritage Dictionary of the English Language
  4. trepan: Collins English Dictionary
  5. trepan: Vocabulary.com
  6. trepan: Wordnik
  7. trepan: Wiktionary
  8. trepan: Webster's New World College Dictionary, 4th Ed.
  9. trepan: The Wordsmyth English Dictionary-Thesaurus
  10. trepan: Infoplease Dictionary
  11. trepan: Dictionary.com
  12. trepan (v.): Online Etymology Dictionary
  13. Trepan (drill bit), Trepan: Wikipedia, the Free Encyclopedia
  14. Trepan: Online Plain Text English Dictionary
  15. trepan: Webster's Revised Unabridged, 1913 Edition
  16. trepan: Rhymezone
  17. Trepan: AllWords.com Multi-Lingual Dictionary
  18. trepan: Webster's 1828 Dictionary
  19. trepan: FreeDictionary.org
  20. trepan: The Phrontistery - A Dictionary of Obscure Words
  21. trepan: Mnemonic Dictionary
  22. trepan: TheFreeDictionary.com

Business (1 matching dictionary)
  1. trepan: Legal dictionary

Medicine (4 matching dictionaries)
  1. Dorland's Illustrated Medical Dictionary (No longer online)
  2. online medical dictionary (No longer online)
  3. Probert Encyclopaedia of Medicine (No longer online)
  4. trepan: Medical dictionary

Miscellaneous (1 matching dictionary)
  1. trepan: Wordcraft Dictionary

Slang (1 matching dictionary)
  1. trepan: Green’s Dictionary of Slang

(Note: See trepanation as well.)

Definitions from Wiktionary (trepan)

noun:  A tool used to bore through rock when sinking shafts.
noun:  (medicine) A surgical instrument used to remove a circular section of bone from the skull; a trephine.
verb:  (transitive, manufacturing, mining) To create a large hole by making a narrow groove outlining the shape of the hole and then removing the plug of material remaining by less expensive means.
verb:  (medicine) To use a trepan; to trephine.
noun:  Alternative spelling of trapan (“act of entrapping or tricking; thing which entraps or tricks; (archaic or obsolete) person (or occasionally an animal) that traps or tricks another into doing something that benefits them but harms the victim”) [An act of entrapping or tricking; an entrapment; also, a thing which entraps or tricks; a snare or trap; a stratagem or trick.]
verb:  Alternative spelling of trapan (“to catch or entrap (a person or animal) in a snare or trap; (figurative) to trap or trick (someone), especially by using some stratagem, into doing something that benefits the perpetrator but harms the victim”) [To catch or entrap (a person or animal) in a snare or trap; to ensnare, to trap.]

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