Usually means: In a difficult or hopeless situation.
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We found 27 dictionaries that define the word screwed:

General (20 matching dictionaries)
  1. screwed: Merriam-Webster
  2. screwed: Oxford Learner's Dictionaries
  3. screwed: Collins English Dictionary
  4. screwed: Vocabulary.com
  5. screwed: Wordnik
  6. screwed: Cambridge Advanced Learner's Dictionary
  7. screwed: Wiktionary
  8. screwed: Webster's New World College Dictionary, 4th Ed.
  9. screwed: Infoplease Dictionary
  10. screwed: Dictionary.com
  11. screwed: Cambridge Essential American English Dictionary
  12. Screwed: Wikipedia, the Free Encyclopedia
  13. Screwed: Online Plain Text English Dictionary
  14. Screwed: AllWords.com Multi-Lingual Dictionary
  15. screwed: Webster's 1828 Dictionary
  16. screwed: MyWord.info
  17. Screwed: Dictionary of Phrase and Fable (1898)
  18. screwed: FreeDictionary.org
  19. screwed: TheFreeDictionary.com
  20. screwed: Wikimedia Commons US English Pronunciations

Computing (1 matching dictionary)
  1. screwed: Encyclopedia

Medicine (1 matching dictionary)
  1. screwed: Medical dictionary

Miscellaneous (2 matching dictionaries)
  1. SCREWED: Acronym Finder
  2. screwed: Idioms

Slang (3 matching dictionaries)
  1. screwed: Green’s Dictionary of Slang
  2. screwed: English slang and colloquialisms used in the United Kingdom
  3. Screwed: Dublin Slang and Phrasebook

(Note: See screw as well.)

Definitions from Wiktionary (screwed)

adjective:  (slang, mildly vulgar) Beset with unfortunate circumstances that seem difficult or impossible to overcome; in imminent danger.
adjective:  (slang, British, dated) Intoxicated.

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