Usually means: Cunningly wicked, devilish, and deceitful.
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We found 15 dictionaries that define the word mephistophelean:

General (12 matching dictionaries)
  1. Mephistophelean: Merriam-Webster
  2. Mephistophelean: Oxford Learner's Dictionaries
  3. Mephistophelean: Collins English Dictionary
  4. mephistophelean: Vocabulary.com
  5. Mephistophelean, mephistophelean: Wordnik
  6. Mephistophelean, mephistophelean: Wiktionary
  7. Mephistophelean: Webster's New World College Dictionary, 4th Ed.
  8. mephistophelean: Dictionary.com
  9. mephistophelean: Rhymezone
  10. mephistophelean: FreeDictionary.org
  11. mephistophelean: Mnemonic Dictionary
  12. Mephistophelean: TheFreeDictionary.com

Business (1 matching dictionary)
  1. mephistophelean: Legal dictionary

Computing (1 matching dictionary)
  1. mephistophelean: Encyclopedia

Slang (1 matching dictionary)
  1. Mephistophelean: Urban Dictionary

(Note: See mephistopheles as well.)

Definitions from Wiktionary (Mephistophelean)

adjective:  Showing the cunning or ingenuity or wickedness typical of a devil.
adjective:  Alternative letter-case form of Mephistophelean [Showing the cunning or ingenuity or wickedness typical of a devil.]

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