Usually means: Go off the planned track.
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We found 31 dictionaries that define the word derail:

General (26 matching dictionaries)
  1. derail: Merriam-Webster
  2. derail: Oxford Learner's Dictionaries
  3. derail: American Heritage Dictionary of the English Language
  4. derail: Collins English Dictionary
  5. derail: Vocabulary.com
  6. Derail, derail: Wordnik
  7. derail: Cambridge Advanced Learner's Dictionary
  8. derail: Wiktionary
  9. derail: Webster's New World College Dictionary, 4th Ed.
  10. derail: The Wordsmyth English Dictionary-Thesaurus
  11. derail: Infoplease Dictionary
  12. Derail, derail: Dictionary.com
  13. derail: Online Etymology Dictionary
  14. derail: Cambridge Essential American English Dictionary
  15. Derail (railroad), Derail: Wikipedia, the Free Encyclopedia
  16. Derail: Online Plain Text English Dictionary
  17. derail: Webster's Revised Unabridged, 1913 Edition
  18. derail: Rhymezone
  19. Derail: AllWords.com Multi-Lingual Dictionary
  20. derail: FreeDictionary.org
  21. derail: Mnemonic Dictionary
  22. derail: TheFreeDictionary.com
  23. derail: Wikimedia Commons US English Pronunciations
  24. derail: Longman Dictionary of Contemporary English

Business (1 matching dictionary)
  1. derail: Legal dictionary

Computing (1 matching dictionary)
  1. derail: Encyclopedia

Medicine (1 matching dictionary)
  1. derail: Medical dictionary

Slang (2 matching dictionaries)
  1. derail: Green’s Dictionary of Slang
  2. derail: Urban Dictionary

(Note: See derailed as well.)

Definitions from Wiktionary (
)
American English Definition British English Definition
noun:  Synonym of derailer: A device placed on railway tracks in order to cause a train to derail.
noun:  An instance of diverting a conversation or debate from its original topic.
verb:  (transitive) To cause to come off the tracks.
verb:  (intransitive) To come off the tracks.
verb:  (intransitive, figurative) To deviate from the previous course or direction.
verb:  (transitive, figurative) To cause to deviate from a set course or direction.

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