Usually means: Reduce the number of inhabitants.
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We found 27 dictionaries that define the word depopulate:

General (24 matching dictionaries)
  1. depopulate: Merriam-Webster
  2. depopulate: Oxford Learner's Dictionaries
  3. depopulate: American Heritage Dictionary of the English Language
  4. depopulate: Collins English Dictionary
  5. depopulate: Vocabulary.com
  6. depopulate: Wordnik
  7. depopulate: Cambridge Advanced Learner's Dictionary
  8. depopulate: Wiktionary
  9. depopulate: Webster's New World College Dictionary, 4th Ed.
  10. depopulate: The Wordsmyth English Dictionary-Thesaurus
  11. depopulate: Infoplease Dictionary
  12. Depopulate, depopulate: Dictionary.com
  13. depopulate: Online Etymology Dictionary
  14. Depopulate: Online Plain Text English Dictionary
  15. depopulate: Webster's Revised Unabridged, 1913 Edition
  16. depopulate: Rhymezone
  17. Depopulate: AllWords.com Multi-Lingual Dictionary
  18. depopulate: Webster's 1828 Dictionary
  19. depopulate: FreeDictionary.org
  20. depopulate: Mnemonic Dictionary
  21. depopulate: TheFreeDictionary.com
  22. depopulate: Longman Dictionary of Contemporary English

Business (1 matching dictionary)
  1. depopulate: Legal dictionary

Medicine (1 matching dictionary)
  1. depopulate: Medical dictionary

Slang (1 matching dictionary)
  1. depopulate: Urban Dictionary

(Note: See depopulated as well.)

Definitions from Wiktionary (
)
American English Definition British English Definition
verb:  (transitive) To reduce the population of a region by disease, war, forced relocation etc.
verb:  (transitive, electronics) To remove the components from a circuit board.
verb:  (intransitive) To become depopulated, to lose its population.
adjective:  (obsolete) Depopulated.

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