Usually means: Destroy something completely and utterly.
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We found 32 dictionaries that define the word annihilate:

General (27 matching dictionaries)
  1. annihilate: Merriam-Webster
  2. annihilate: Oxford Learner's Dictionaries
  3. annihilate: American Heritage Dictionary of the English Language
  4. annihilate: Collins English Dictionary
  5. annihilate: Vocabulary.com
  6. Annihilate, annihilate: Wordnik
  7. annihilate: Cambridge Advanced Learner's Dictionary
  8. annihilate: Wiktionary
  9. annihilate: Webster's New World College Dictionary, 4th Ed.
  10. annihilate: The Wordsmyth English Dictionary-Thesaurus
  11. annihilate: Infoplease Dictionary
  12. Annihilate, annihilate: Dictionary.com
  13. annihilate: Online Etymology Dictionary
  14. annihilate: Cambridge Essential American English Dictionary
  15. Annihilate: Online Plain Text English Dictionary
  16. annihilate: Webster's Revised Unabridged, 1913 Edition
  17. annihilate: Rhymezone
  18. annihilate: AllWords.com Multi-Lingual Dictionary
  19. annihilate: Webster's 1828 Dictionary
  20. annihilate: FreeDictionary.org
  21. annihilate: Mnemonic Dictionary
  22. annihilate: TheFreeDictionary.com
  23. annihilate: Wikimedia Commons US English Pronunciations
  24. annihilate: Longman Dictionary of Contemporary English
  25. annihilate: Merriam-Webster

Business (1 matching dictionary)
  1. annihilate: Legal dictionary

Computing (1 matching dictionary)
  1. annihilate: Encyclopedia

Medicine (2 matching dictionaries)
  1. online medical dictionary (No longer online)
  2. annihilate: Medical dictionary

Slang (1 matching dictionary)
  1. Annihilate, annihilate: Urban Dictionary

(Note: See annihilated as well.)

Definitions from Wiktionary (
)
American English Definition British English Definition
verb:  To reduce to nothing, to destroy, to eradicate.
verb:  (particle physics) To react with antimatter, producing gamma radiation and (for higher-mass reactants, especially composite particles such as protons) lighter particles (such as pions, muons, and neutrinos).
verb:  (archaic) To treat as worthless, to vilify.
verb:  (transitive) To render null and void; to abrogate.

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