Usually means: Consumed, depleted, no longer usable.
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We found 13 dictionaries that define the word used up:

General (8 matching dictionaries)
  1. used up: Merriam-Webster
  2. used up: Collins English Dictionary
  3. used up: Vocabulary.com
  4. used-up: Wordnik
  5. used up: Wiktionary
  6. Used Up: E Cobham Brewer, The Reader's Handbook
  7. Used Up: Dictionary of Phrase and Fable (1898)
  8. used up: TheFreeDictionary.com

Business (1 matching dictionary)
  1. used up: Legal dictionary

Computing (1 matching dictionary)
  1. used up: Encyclopedia

Medicine (1 matching dictionary)
  1. used up: Medical dictionary

Miscellaneous (1 matching dictionary)
  1. used up: Idioms

Slang (1 matching dictionary)
  1. used up: Green’s Dictionary of Slang

Definitions from Wiktionary (used up)

adjective:  Worn out; depleted; exhausted; having nothing left; useless, due to the expenditure of all resources.

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