Might mean (unverified): Feminization fetish involving emasculation role-play.
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We found one dictionary that defines the word sissyfication:

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  1. sissyfication: Wiktionary

Definitions from Wiktionary (sissyfication)

noun:  (informal, derogatory) The act or process of sissifying.
noun:  (BDSM) A situation where a submissive is forced to take on a feminine role, that of a sissy.

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