Usually means: Effeminate behavior in some males.
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We found 26 dictionaries that define the word sissy:

General (22 matching dictionaries)
  1. sissy: Longman Dictionary of Contemporary English
  2. sissy: Merriam-Webster
  3. sissy, sissy: Oxford Learner's Dictionaries
  4. sissy: American Heritage Dictionary of the English Language
  5. sissy: Collins English Dictionary
  6. sissy: Vocabulary.com
  7. Sissy: Wordnik
  8. sissy: Cambridge Advanced Learner's Dictionary
  9. Sissy, sissy: Wiktionary
  10. sissy: Webster's New World College Dictionary, 4th Ed.
  11. sissy: The Wordsmyth English Dictionary-Thesaurus
  12. sissy: Infoplease Dictionary
  13. sissy: Dictionary.com
  14. sissy: Online Etymology Dictionary
  15. sissy: Cambridge Essential American English Dictionary
  16. Sissy (disambiguation), Sissy (transgender), Sissy: Wikipedia, the Free Encyclopedia
  17. sissy: Rhymezone
  18. sissy: FreeDictionary.org
  19. sissy: Mnemonic Dictionary
  20. sissy: TheFreeDictionary.com

Computing (1 matching dictionary)
  1. sissy: Encyclopedia

Miscellaneous (1 matching dictionary)
  1. baby names list (No longer online)

Slang (2 matching dictionaries)
  1. sissy, sissy: Green’s Dictionary of Slang
  2. sissy: English slang and colloquialisms used in the United Kingdom

(Note: See sissies as well.)

Definitions from Wiktionary (
)
American English Definition British English Definition
noun:  (sometimes derogatory, colloquial) An effeminate boy or man.
noun:  (sometimes derogatory, colloquial) A timid, unassertive or cowardly person.
noun:  (BDSM) A male crossdresser who adopts feminine behaviours.
noun:  (dated, colloquial) Sister; often used as a term of address
adjective:  (derogatory) Effeminate.
adjective:  (derogatory) Cowardly.
noun:  (childish, colloquial) Urination; urine.
verb:  (childish, colloquial) To urinate.
verb:  (intransitive, slang, vulgar, rare) To sissygasm (reach orgasm solely by penetration of the anus).
noun:  A diminutive of the female given name Cecilia.

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