Usually means: Response indicating biological activity presence.
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We found 4 dictionaries that define the word sign of life:

General (4 matching dictionaries)
  1. sign of life: Longman Dictionary of Contemporary English
  2. sign of life: Wiktionary

Definitions from Wiktionary (sign of life)

noun:  An indication that someone is alive; vital sign.
noun:  (figuratively) An indication that someone is present.

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