Usually means: Most severe or extreme condition.
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We found 15 dictionaries that define the word sickest:

General (10 matching dictionaries)
  1. sickest: Merriam-Webster
  2. sickest: Collins English Dictionary
  3. sickest: Vocabulary.com
  4. Sickest, sickest: Wordnik
  5. sickest: Cambridge Advanced Learner's Dictionary
  6. sickest: Wiktionary
  7. sickest: Dictionary.com
  8. sickest: Cambridge Essential American English Dictionary
  9. sickest: FreeDictionary.org
  10. sickest: TheFreeDictionary.com

Computing (1 matching dictionary)
  1. sickest: Encyclopedia

Medicine (2 matching dictionaries)
  1. sickest: Merriam-Webster Medical Dictionary
  2. sickest: Medical dictionary

Miscellaneous (1 matching dictionary)
  1. sickest: Idioms

Slang (1 matching dictionary)
  1. sickest: Urban Dictionary

(Note: See sick as well.)

Definitions from Wiktionary (sick)

adjective:  (less common in the UK and Ireland) In poor health; ill.
adjective:  Having an urge to vomit.
adjective:  (colloquial) Mentally unstable, disturbed.
adjective:  (colloquial) In bad taste.
adjective:  Tired of or annoyed by something [with of].
adjective:  (slang) Very good, excellent, awesome, badass.
adjective:  In poor condition.
adjective:  (agriculture) Failing to sustain adequate harvests of crop, usually specified.
noun:  (British, Australia, colloquial) Vomit.
noun:  (British, colloquial) (especially in the phrases on the sick and on long-term sick) Any of various current or former benefits or allowances paid by the Government to support the sick, disabled or incapacitated.
verb:  (British, Australia, colloquial) To vomit.
verb:  (obsolete except in dialect, intransitive) To fall sick; to sicken.
noun:  A surname from German.
verb:  (rare) Alternative spelling of sic (“set upon”) [To mark with a bracketed sic.]
▸ Also see sick

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