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We found 4 dictionaries that define the word mother's little helper:

General (2 matching dictionaries)
  1. Mother's Little Helper: Wikipedia, the Free Encyclopedia
  2. mother's little helper: Wiktionary

Slang (2 matching dictionaries)
  1. Mother's little helper: Street Terms: Drugs and the Drug Trade
  2. mothers little helper: Urban Dictionary

Definitions from Wiktionary (mother's little helper)

noun:  (slang, euphemistic) A tranquilizer taken to reduce anxiety; meprobamate, diazepam.


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