Usually means: Excited or enhanced, often artificially.
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We found 17 dictionaries that define the word hopped up:

General (12 matching dictionaries)
  1. hopped-up: Merriam-Webster
  2. hopped-up, hopped up: Vocabulary.com
  3. hopped-up: Wordnik
  4. hopped up: Wiktionary
  5. hopped-up: Infoplease Dictionary
  6. hopped-up, hopped up: Dictionary.com
  7. hopped-up: FreeDictionary.org
  8. hopped-up: Mnemonic Dictionary
  9. hopped-up: TheFreeDictionary.com
  10. hopped-up: Rhymezone
  11. hopped up: Longman Dictionary of Contemporary English

Medicine (1 matching dictionary)
  1. hopped up: Medical dictionary

Miscellaneous (1 matching dictionary)
  1. hopped up: Idioms

Slang (3 matching dictionaries)
  1. Hopped up: Street Terms: Drugs and the Drug Trade
  2. Hopped Up: 1960's Slang
  3. hopped up: Urban Dictionary

Definitions from Wiktionary (hopped up)

adjective:  (slang, usually followed by "on") Drugged; intoxicated.
adjective:  (slang) Mechanically enhanced for high performance; souped-up.

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