Usually means: Initially, at the beginning stage.
Definitions Related words Mentions
We found 17 dictionaries that define the word first off:

General (14 matching dictionaries)
  1. first off: Merriam-Webster
  2. first off: Oxford Learner's Dictionaries
  3. first off: Vocabulary.com
  4. first-off: Wordnik
  5. first off: Wiktionary
  6. first off: Dictionary.com
  7. First Off: Wikipedia, the Free Encyclopedia
  8. first off: Rhymezone
  9. first off: FreeDictionary.org
  10. first off: Mnemonic Dictionary
  11. first off: TheFreeDictionary.com
  12. first off: Longman Dictionary of Contemporary English

Computing (1 matching dictionary)
  1. first off: Encyclopedia

Miscellaneous (1 matching dictionary)
  1. first off: Idioms

Slang (1 matching dictionary)
  1. first off: Urban Dictionary

Definitions from Wiktionary (first off)

adverb:  (sequence, idiomatic) Firstly; before anything else. Often used to introduce the first in a list of points to be made in conversation.

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